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Synfacts 2008(4): 0334-0334  
DOI: 10.1055/s-2008-1042883
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of MB06322

Contributor(s): Philip Kocienski
Q. Dang, S. R. Kasibhatla, K. R. Reddy, T. Jiang, M. R. Reddy, S. C. Potter, J. M. Fujitaki, P. D. van Poelje, J. Huang, W. N. Lipscomb, M. D. Erion*
Metabasis Therapeutics, La Jolla and Harvard University, Cambridge, USA
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Publication History

Publication Date:
19 March 2008 (online)

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Significance

MB06322 is an orally available phosphonate diamide prodrug to compound D, a potent inhibitor of fructose-1,6-bisphosphatase (FBPase). FBPase is a rate-limiting enzyme in glucose production whose inhibition offers a potential treatment for type 2 diabetes.