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Synfacts 2008(4): 0403-0403
DOI: 10.1055/s-2008-1042816
DOI: 10.1055/s-2008-1042816
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Gold-Catalyzed Oxidative Coupling
A. Kar, N. Mangu, H. M. Kaiser, M. Beller, M. K. Tse*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock and Universität Rostock, Germany
Further Information
Publication History
Publication Date:
19 March 2008 (online)
Significance
Gold-catalyzed oxidative homocoupling with simple arenes was realized for the first time. C-H functionalization was shown to proceed with remarkable functional group tolerance, where even iodo-substituents were tolerated. For this coupling reaction no inert atmosphere or pretreatment of the solvent was required. The reaction could simply be performed in air without the exclusion of moisture.