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Synfacts 2008(4): 0380-0380  
DOI: 10.1055/s-2008-1042793
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ruthenium-Catalyzed Regio- and Enantioselective O-Allylation

Contributor(s): Mark Lautens, Praew Thansandote
K. Onitsuka*, H. Okuda, H. Sasai
Osaka University, Japan
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Publikationsverlauf

Publikationsdatum:
19. März 2008 (online)

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Significance

A highly regio- and enantioselective O-allylation of phenols and alcohols is described using a planar-chiral cyclopentadienyl ruthenium complex. Allylation predominantly takes place at the more substituted allylic carbon, producing high branched/linear ratios.