Download PDF
Am J Perinatol 1986; 3(3): 165-167
DOI: 10.1055/s-2007-999859
ORIGINAL ARTICLE

© 1986 by Thieme Medical Publishers, Inc.

L-deamino-8-d-Arginine Vasopressin Treatment in Pregnancy and Neonatal Outcome

A Report of Three CasesNejama Linder, Israel Matoth, Gonen Ohel, Debora Yourish, Israel Tamir
  • The Departments of Pediatrics and Obstetrics and Gynecology, Hadassah University Hospital and Hebrew University-Hadassah Medical School, Jerusalem, Israel
Further Information

Publication History

Publication Date:
04 March 2008 (online)

    Permissions and Reprints

ABSTRACT

Three women with neurohypophyseal diabetes insipidus, treated for prolonged periods, including pregnancy, with L-deamino-8-d-arginine vasopressin, gave birth in our hospital. Two of the infants had severe congenital heart disease, one of which was associated with trisomy 21. The third baby, born prematurely, presented with mild intrauterine growth retardation; at the age of 21 months, the boy had severe failure to thrive, hypotonia, and motor retardation. These three cases raise doubts as to the safety of diabetes insipidus or its treatment in pregnancy.

      >