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Am J Perinatol 1987; 4(1): 41-49
DOI: 10.1055/s-2007-999735
ORIGINAL ARTICLE

© 1987 by Thieme Medical Publishers, Inc.

Criteria for the Prenatal Diagnosis of Holoprosencephaly

Gianluigi Pilu, Roberto Romero, Nicola Rizzo, Philippe Jeanty, Luciano Bovicelli, John C. Hobbins
  • Section of Prenatal Pathophysiology, Second Department of Obstetrics and Gynecology, University of Bologna School of Medicine, Bologna, and the Section of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut
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Publikationsdatum:
04. März 2008 (online)

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ABSTRACT

Holoprosencephaly is a congenital anomaly of the central nervous system whose prenatal sonographic appearance may to similar to that of ventriculomegaly. A clear differential diagnosis is extremely important because the two conditions have different prognoses and therefore require different obstetric management. Eight cases of prenatally recognized holoprosencephaly are analyzed and criteria for a specific diagnosis proposed. The specificity and limitations of ultrasound findings, such as identification of a holoventricle, presence of a dorsal sac, and facial anomalies are discussed.