Am J Perinatol 1990; 7(1): 71-74
DOI: 10.1055/s-2007-999450

© 1990 by Thieme Medical Publishers, Inc.

Safety and Efficacy of Long-Term Tocolysis with Indomethacin

Andrew Gerson, Soraya Abbasi, Anthony Johnson, Mark Kalchbrenner, Graham Ashmead, Ronald Bolognese
  • Section of Perinatology and the Section of Newborn Pediatrics, The Department of Obstetrics and Gynecology, The Pennsylvania Hospital, Philadelphia, Pennsylvania
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Publication History

Publication Date:
04 March 2008 (online)


Indomethacin was utilized in 24 pregnancies (31 exposed fetuses) in preterm labor who labored despite intravenous tocolysis. The mean gestational age at the start of indomethacin therapy was 25.1 weeks (±4.4), mean duration of indomethacin therapy was 43.9 days (±31.4), mean gestational age at delivery 33.1 weeks (±3.7). Neonatal follow-up revealed the same incidence of complications in these indomethacin-exposed infants, when they were compared with all other infants born in the same time period and exposed to intravenous tocolytics only when matched for gestational age at delivery.