Am J Perinatol 1990; 7(1): 33-35
DOI: 10.1055/s-2007-999441

© 1990 by Thieme Medical Publishers, Inc.

Evaluation of Potential Early Markers of Chorioamnionitis Associated with Preterm Premature Ruptured Membranes

Gregory Goyert, Honor Wolfe, Rupinder Bhatia, Gwendolyn Norman, Abdel-Monem Farag, Eberhard Mammen
  • Wayne State University School of Medicine, Hutzel Hospital, Department of Obstetrics and Gynecology, Division of Maternal/Fetal Medicine, Department of General Surgery, Detroit, Michigan
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Publication History

Publication Date:
04 March 2008 (online)


Optimal expectant management of preterm premature rupture of membranes (PROM) requires the early detection of chorioamnionitis. To date, however, no universally sensitive and specific marker for chorioamnionitis has been identified. Recently, the serial determination of plasma fibronectin, antithrombin, and prekallikrein has been reported to facilitate the early detection of sepsis in critically ill neonates and adult surgical patients. A cross-sectional study was undertaken to determine if plasma levels of these markers change significantly in patients with overt chorioamnionitis following expectant management of preterm PROM. Plasma levels of fibronectin and prekallikrein were not significantly different between the study (30 patients with overt chorioamnionitis following preterm PROM) and control (30 undelivered patients without antenatal complication matched for gestational age) groups. Antithrombin levels were significantly lower in the study group (p < 0.05), but the magnitude of the difference (102% versus 94%) is not likely to be of clinical significance. We conclude that determination of plasma levels of fibronectin, prekallikrein, and antithrombin is not likely to aid in the early detection of chorioamnionitis in the setting of preterm (PROM).