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Am J Perinatol 1992; 9(5/06): 448-451
DOI: 10.1055/s-2007-999286
ORIGINAL ARTICLE

© 1992 by Thieme Medical Publishers, Inc.

Neonatal Alloimmune Thrombocytopenia After Maternal Immunization with Paternal Mononuclear Cells: Successful Treatment with Intravenous Gamma Globulin

S. A. Pearlman, R. S. Meek, F. S. Cowchock, J. B. Smith, J. McFarland, R. H. Aster
  • Department of Pediatrics, Medical Center of Delaware, Newark, Delaware; Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania; and Blood Center Southeastern Wisconsin
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Publication Date:
04 March 2008 (online)

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ABSTRACT

We report a case of neonatal alloimmune thrombocytopenia and intracranial hemorrhage in an infant whose mother received immunizations of paternal mononuclear cells. This therapy is designed to prevent unexplained first trimester miscarriages. No previous cases of platelet autoimmunization associated with maternal immunization with paternal mononuclear cells has been reported. Treatment with antenatal maternal infusions of intravenous gamma globulin (IVGG) did not prevent fetal thrombocytopenia, but IVGG may become the treatment of choice for postnatal, antibody-mediated thrombocytopenia of the newborn.