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Am J Perinatol 1993; 10(5): 404-406
DOI: 10.1055/s-2007-994773
ORIGINAL ARTICLE

© 1993 by Thieme Medical Publishers, Inc.

Congenital Cytomegalovirus Infection Presenting as Cerebral Ventriculomegaly on Antenatal Sonography

Diane M. Twickler1 , 2 , Jeffrey Perlman3 , Mark C. Maberry1
  • 1Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas
  • 2Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas
  • 3Department of Pediatric, The University of Texas Southwestern Medical Center, Dallas, Texas
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Publication Date:
04 March 2008 (online)

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ABSTRACT

Antenatal sonography in two cases demonstrated cerebral ventriculomegaly and decreased head circumference, subsequently found to be secondary to cytomegalovirus (CMV) infection. In both cases, the lateral ventricles were enlarged and lissencephaly was diagnosed in the neonatal period. The findings of ventriculomegaly and decreased head circumference on antenatal sonography warrant further investigation for CMV via amniotic fluid cultures or fetal blood, given the poor prognosis in infants with symptomatic infection.