Congenital Cytomegalovirus Infection Presenting as Cerebral Ventriculomegaly on Antenatal Sonography

Diane M. Twickler; Jeffrey Perlman; Mark C. Maberry

doi:10.1055/s-2007-994773

American Journal of Perinatology, Table of Contents

Am J Perinatol 1993; 10(5): 404-406
DOI: 10.1055/s-2007-994773

ORIGINAL ARTICLE

Congenital Cytomegalovirus Infection Presenting as Cerebral Ventriculomegaly on Antenatal Sonography

Diane M. Twickler¹ ^, ² , Jeffrey Perlman³ , Mark C. Maberry¹

¹Department of Obstetrics and Gynecology, The University of Texas Southwestern Medical Center, Dallas, Texas
²Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas
³Department of Pediatric, The University of Texas Southwestern Medical Center, Dallas, Texas

Abstract

ABSTRACT

Antenatal sonography in two cases demonstrated cerebral ventriculomegaly and decreased head circumference, subsequently found to be secondary to cytomegalovirus (CMV) infection. In both cases, the lateral ventricles were enlarged and lissencephaly was diagnosed in the neonatal period. The findings of ventriculomegaly and decreased head circumference on antenatal sonography warrant further investigation for CMV via amniotic fluid cultures or fetal blood, given the poor prognosis in infants with symptomatic infection.

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