Am J Perinatol 1993; 10(2): 119-125
DOI: 10.1055/s-2007-994642

© 1993 by Thieme Medical Publishers, Inc.

Doppler Flowmeter-Assessed Circadian Rhythms in Neonatal Cardiac Function, Family History, and Intrauterine Growth Retardation

Zhengrong Wang, Xuechuan Sun, Germaine Cornélissen, Jinyi Wu, Ling Meng, Degui Cai, Zhennan Xue, Franz Halberg
  • Biomedical Engineering Unit, West China University of Medical Sciences, Chengdu, China
  • Chengdu Physical Culture College, Chengdu, China
  • Chronobiology Laboratories, University of Minnesota, Minneapolis, Minnesota
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Publication History

Publication Date:
04 March 2008 (online)


This study examines the circadian variation of aortic blood flow velocity, acceleration, and distance of stroke, assessed every 4 hours for 24 hours by Doppler ultrasound in 88 human newborns. Groups 1 and 2 involve neonates with a negative family history of high blood pressure or myocardial infarction monitored during the first day or between the second and tenth days postpartum, respectively; groups 3 to 6 are 2- to 10-day-old babies with a positive family history of high blood pressure (group 3) or of myocardial infarction (group 4) or with a negative family history and intrauterine growth retardation (group 5) or born prematurely (group 6). Cosinor analyses demonstrate a circadian rhythm for all variables in groups 2 and 5 (p <0.001), with overall high values occurring around 17:40. In group 2, a circadian rhythm remains demonstrable in boys and girls considered separately, and mostly so in arbitrary subgroups of different sizes, with only slight differences in rhythm parameters among them. These results show that, with relatively small samples, reproducible circadian rhythms of cardiac function can be detected shortly after birth in neonates with a negative family history of high blood pressure or myocardial infarction.