Am J Perinatol 1998; 15(11): 629-633
DOI: 10.1055/s-2007-994081

© 1998 by Thieme Medical Publishers, Inc.

Sporadic Congenital Infantile Cortical Hyperostosis (Caffey's Disease)

Khalil Ibrahim Al-Tawil1 , Gasudraz Salim Ahmed1 , Muneef Mahrout Al-Hathal1 , Mohammed Abdullah Al-Zuwayed2
  • 1Department of Paediatrics, Neonatology Division, King Fahad National Guard Hospital, Riyadh, Saudi Arabia
  • 2Department of E.N.T. Surgery, King Fahad National Guard Hospital, Riyadh, Saudi Arabia
Further Information

Publication History

Publication Date:
04 March 2008 (online)


Prognosis of congenital infantile cortical hyperostosis (Caffey's disease) is poor particularly in premature babies. Two cases are presented of congenital Caffey's disease in premature babies. The first baby was hydropic at birth and had cortical hyperostosis involving the mandible and long bones of right upper limb and both lower limbs. The second baby had cortical hyperostosis of the nasal bones causing severe nasal nonchoanal stenosis that needed surgery, in addition to involvement of long bones of the four extremities. Both babies recovered from the disease and were discharged home well. These cases suggest that the improved outcome of congenital of infantile cortical hyperostosis may reflect improvement of neonatal mechanical ventilation and availability of neonatal total parenteral nutrition.