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Am J Perinatol 1998; 15(7): 427-429
DOI: 10.1055/s-2007-993970
ORIGINAL ARTICLE

© 1998 by Thieme Medical Publishers, Inc.

Stem Cell Factor (SCF) Levels in Newborns

Ayse Savas, Selma Ince, Mesut Coskun, Senay Durmaz, Olcay Yegin
  • Akdeniz University Faculty of Medicine, Antalya/Turkey. This study was supported by Akdeniz University Research Fund.
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Publication Date:
04 March 2008 (online)

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ABSTRACT

We studied Stem cell factor (SCF) levels in 15 mother-newborn pairs, 15 healthy adult controls, and 16 newborn with bacterial sepsis. SCF levels were also determined in six newborns with sepsis before and after completion of treatment. SCF levels (pg/mL) were found to be 2141 ± 529 in cord blood, 1385 ± 314 in mothers, 1546 ± 443 in healthy adult controls, and 1742 ± 655 in septic newborns. Cord blood SCF levels were significantly higher than their mothers' and healthy controls (p <0.05). There were no differences in SCF levels between mothers and healthy adult controls. No correlation was found between the SCF levels and absolute neutrophil counts. There were no differences in SCF levels between the before and after treatment levels in six newborn with sepsis. In conclusion, our study suggests that SCF levels were increased in cord blood, and this increase is not a reflection of mothers' levels. SCF levels do not show significant changes during sepsis in newborns.

Keywords

Stem cell factor - newborn - sepsis neutrophil