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Pharmacopsychiatry 2007; 40: S2-S16
DOI: 10.1055/s-2007-993139
Original Paper

© Georg Thieme Verlag KG Stuttgart · New York

“Computational Neuropsychiatry” of Working Memory Disorders in Schizophrenia: The Network Connectivity in Prefrontal Cortex - Data and Models

F. Tretter 1 , M. Albus 1
  • 1Department of Addiction, Isar-Amper-Hospital, Haar/Munich, Germany
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Publication History

Publication Date:
17 December 2007 (online)

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Abstract

The use of mathematical and computer-assisted modeling of brain mechanisms involved in mental disorders can be called “Computational Neuropsychiatry”. It was already demonstrated by several initiatives that computational modeling is an important contribution to understand neuronal circuits that could generate mental functions and dysfunctions. However, this attempt needs close collaboration between experimental neurobiologists, clinical psychiatry and systems science. In order to do so, we have organized a series of workshops on computational neuropsychiatry. Here we try to give basic information on data and modeling of the prefrontal cortical neurocircuitry that is involved in working memory and its disorders in schizophrenia. Special emphasis is devoted to the basic features of computational modeling.

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Correspondence

Prof. Dr. Dr. Dr. F. Tretter

Department of Addiction

Isar-Amper-Hospital

Ringstr. 9

85529 Haar/Munich

Germany

Phone: 00 49/89/4562 37 08

Fax: 00 49/89/4562 37 54

Email: Felix.Tretter@IAK-KMO.de

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