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Synfacts 2008(2): 0181-0181  
DOI: 10.1055/s-2007-992493
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Enantioselective Synthesis of Substituted Indenols

Contributor(s): Mark Lautens, Frédéric Ménard
M. Yang, X. Zhang, X. Lu*
Shanghai Institute of Organic Chemistry, P. R. of China and Rutgers, State University of New Jersey, Piscataway, USA
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Publikationsdatum:
23. Januar 2008 (online)

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Significance

The enantioselective synthesis of 1-indenol has proven to be an elusive goal. The above formal [3+2] annulation approach yielded indenols 4 in high enantioselectivity. The operational simplicity of the reaction makes it attractive.