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Synfacts 2008(2): 0185-0185  
DOI: 10.1055/s-2007-992472
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Zn(II)- or Rh(II)-Catalyzed Synthesis of Multisubstituted Pyrroles from Dienyl Azides

Contributor(s): Paul Knochel, Tobias Thaler
H. Dong, M. Shen, J. E. Redford, B. J. Stokes, A. L. Pumphrey, T. G. Driver*
University of Illinois at Chicago, USA
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Publikationsdatum:
23. Januar 2008 (online)

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Significance

Multisubstituted pyrroles are important skeletons for biologically active compounds and natural products. In this article, a new mild way for the synthesis of 2,5-di- and 2,4,5-trisubstituted pyrroles from dienyl azides is reported. The reaction proceeds even at room temperature with inexpensive ZnI2 as catalyst.