Regio- and Enantioselective Cycloadditions of Nitrones

Significance

This is one of the rare examples of a successful protocol for highly regio- and enan­tioselective cycloaddition of nitrones and meth­acrolein. The most important features of this methodology are the high regioselectivity observed and the generation of a quaternary stereocenter. Furthermore, the method can be efficiently employed for the reaction with crotonaldehyde.