ABSTRACT
Managing a pharyngocutaneous fistula in patients who have had total laryngectomy and
radiotherapy is difficult. The purpose of this study was to review our experience
using anterolateral thigh flaps to repair these defects. Between May 2002 and May
2006, pharyngocutaneous fistulas were repaired in nine consecutive patients. The first
five patients had been managed conservatively for several months before repair was
performed. The recent four patients were repaired within 1 month of fistula formation.
Eight patients had frozen necks, which required neck resurfacing. Risky carotid artery
exposure was avoided by using the transverse cervical vessels as recipient vessels.
Pharyngocutaneous fistulas occurred between 8 and 30 days after a total laryngectomy.
Early repair was much easier than late repair due to severe scaring and stricture
associated with long-standing fistulas. All flaps survived. The mean hospitalization
was 7 days. No recurrent fistulas or strictures developed after 11 to 48 months of
follow-up. All patients achieved 100% oral alimentation. Five of the six patients
eligible for tracheoesophageal puncture achieved fluent speech. Using the multi-island
anterolateral thigh flap and transverse cervical vessels in pharyngeal reconstruction
provides quick recoveries and excellent functional outcomes. Early repair is strongly
recommended once a postlaryngectomy pharyngocutaneous fistula is identified.
KEYWORDS
Pharyngocutaneous fistula - anterolateral thigh flap - perforator flap - tracheostoma
reconstruction - head and neck reconstruction
REFERENCES
- 1
Wolf G T, Hong W K, Fisher S G et al..
Induction chemotherapy plus radiation compared with surgery plus radiation in patients
with advanced laryngeal cancer.
N Engl J Med.
1991;
324
1685-1690
- 2
Leon X, Quer M, Orus C et al..
Results of salvage surgery for local or regional recurrence after larynx preservation
with induction chemotherapy and radiotherapy.
Head Neck.
2001;
23
733-738
- 3
Moore B A, Holsinger F C, Diaz E M, Weber R S.
Organ preservation surgery in the era of chemoradiation.
Curr Probl Cancer.
2005;
29
169-179
- 4
Genden E M, Rinaldo A, Shaha A R et al..
Pharyngocutaneous fistula following laryngectomy.
Acta Otolaryngol.
2004;
124
117-120
- 5
McCombe A W, Jones A S.
Radiotherapy and complications of laryngectomy.
J Laryngol Otol.
1993;
107
130-132
- 6
Hier M, Black M J, Lafond G.
Pharyngo-cutaneous fistulas after total laryngectomy: incidence, etiology, and outcome
analysis.
J Otolaryngol.
1993;
22
164-166
- 7
Natvig K, Boysen M, Tausjo J.
Fistulae following laryngectomy in patients treated with irradiation.
J Laryngol Otol.
1993;
107
1136-1139
- 8
Weber R S, Berkey B B, Forastiere A A et al..
Outcome of salvage total laryngectomy following organ preservation therapy: the Radiation
Therapy Oncology Group Trial 91-11.
Arch Otolaryngol Head Neck Surg.
2003;
129
44-49
- 9
Yu P.
Characteristics of the anterolateral thigh flap in a western population and its application
in head and neck reconstruction.
Head Neck.
2004;
26
759-769
- 10
Yu P.
The transverse cervical vessels as recipient vessels for previously treated head and
neck cancer patients.
Plast Reconstr Surg.
2005;
115
1253-1258
- 11
McCarthy C M, Kraus D H, Cordeiro P G.
Tracheostomal and cervical esophageal reconstruction with combined deltopectoral flap
and microvascular free jejunal transfer after central neck exenteration.
Plast Reconstr Surg.
2005;
115
1304-1310
- 12
Fowler B Z, Muller S, Chen A Y, Johnstone P AS.
Factors influencing long-term survival following salvage total laryngectomy after
initial radiotherapy or conservative surgery.
Head Neck.
2006;
28
99-106
- 13
Forastiere A A, Goepfert H, Maor M et al..
Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal
cancer.
N Engl J Med.
2003;
349
2091-2098
- 14
Goodwin Jr W J.
Salvage surgery for patients with recurrent squamous cell carcinoma of the upper aerodigestive
tract: when do the ends justify the means?.
Laryngoscope.
2000;
110(suppl 93)
1-18
- 15
Disa J J, Cordeiro P G.
Reconstruction of the hypopharynx and cervical esophagus.
Clin Plast Surg.
2001;
28
349-360
- 16
Reece G P, Bengtson B P, Schusterman M A.
Reconstruction of the pharynx and cervical esophagus using free jejunal transfer.
Clin Plast Surg.
1994;
21
125-147
- 17
Schuller D E.
Limitations of the pectoralis major myocutaneous flap in head and neck cancer reconstruction.
Arch Otolaryngol.
1980;
106
709-714
- 18
Demir Z, Velidedeoglu H, Celebioglu S.
Repair of pharyngocutaneous fistulas with the submental artery island flap.
Plast Reconstr Surg.
2005;
115
38-44
Peirong YuM.D.
Department of Plastic Surgery, Unit 443, The University of Texas M.D. Anderson Cancer
Center
1515 Holcombe Boulevard, Houston, TX 77030