Association between plasma atrial natriuretic peptide, ß-endorphin and anxiety in mice during acute ethanol withdrawal

C. von der Goltz; J. Mutschler; F. Kiefer

doi:10.1055/s-2007-991824

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Pharmacopsychiatry 2007; 40 - A149
DOI: 10.1055/s-2007-991824

Association between plasma atrial natriuretic peptide, ß-endorphin and anxiety in mice during acute ethanol withdrawal

C von der Goltz ¹, J Mutschler ¹, F Kiefer ¹

¹Department of Addictive Behavior and Addiction Medicine, Germany

Congress Abstract

Aims: To evaluate the anxiolytic activity of atrial natriuretic peptide (ANP) and ß-endorphin during alcohol withdrawal. Methods: 24 male mice (C57/Bl6J) were studied following 21 days of free-choice and forced alcohol intake. Anxiety related behavior (elevated plus maze, open field) was tested during acute ethanol withdrawal (12 hours after last ethanol consumption). 30 minutes before testing, randomized groups of mice were given i.p. injections of ANP (60µg/kg), ß-endorphin (2µg/kg) or saline. Results: Acute alcohol withdrawal in alcohol habituated mice was associated with increased anxiety related behavior. Application of both, ß-endorphin and ANP, was significantly associated with reduced anxiety related behavior. Conclusions: Our results complement the data from clinical trials regarding the involvement of ANP and ß-endorphin in withdrawal-induced anxiety in alcohol related disorders.