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Synfacts 2007(12): 1271-1271  
DOI: 10.1055/s-2007-991375
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Iron-Catalyzed Epoxidations with Hydrogen Peroxide

Contributor(s): Mark Lautens, Michael Langer
F. G. Gelalcha, B. Bitterlich, G. Anilkumar, M. K. Tse, M. Beller*
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Germany
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

Asymmetric epoxidations give enantioenriched oxiranes which are versatile intermediates in fine chemical synthesis. Currently, most methods involve either atom-inefficient oxidants or the use of expensive transition metals. The authors report an iron catalyst/hydrogen peroxide based method to access chiral oxiranes in high yields and moderate to high enantioselectivities.