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Synfacts 2007(12): 1290-1290  
DOI: 10.1055/s-2007-991347
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Asymmetric 1,2-Addition of Organoalanes to Cyclic Enones

Contributor(s): Hisashi Yamamoto, Marina Naodovic
J. Siewert, R. Sandmann, P. von Zezschwitz*
Georg-August-Universität Göttingen, Germany
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Publication History

Publication Date:
22 November 2007 (online)

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Significance

This is one of the first examples of asymmetric Rh-catalyzed 1,2-addition reactions to cyclic enones lacking substituents in the α-position. This methodology provides easy access to tertiary alcohols with high enantioselectivity and good to excellent yields using the readily available Rh-binap complex and various inexpensive organoaluminum reagents.