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Synfacts 2007(12): 1295-1295
DOI: 10.1055/s-2007-991330
DOI: 10.1055/s-2007-991330
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New YorkAlkynylation of Epoxides with Alkynylalanes at the More Hindered Carbon
H. Zhao, D. W. Engers, C. L. Morales, B. L. Pagenkopf*
The University of Western Ontario, London, Canada and the University of Texas at Austin, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. November 2007 (online)

Significance
Epoxides are important building blocks in organic synthesis; they are relatively readily available in enantiopure forms. This is the first general method for the addition of carbanions to the more hindered position of trisubstituted epoxides. The nucleophilic ring opening by aluminates results in the completely stereoselective formation of an all-carbon quaternary center in a chemoselective fashion. This approach allows a simple stereoselective construction of relatively complex carbon frameworks.