RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2007(11): 1193-1193
DOI: 10.1055/s-2007-991232
DOI: 10.1055/s-2007-991232
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Olefins by Cross-Coupling of N-Tosylhydrazones with Aryl Halides
J. Barluenga*, P. Moriel, C. Valdés, F. Aznar
Universidad de Oviedo, Spain
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Oktober 2007 (online)
Significance
The authors report herein an elegant protocol for a new C-C bond formation, which can be formally considered as a combination of the Shapiro reaction and a Pd-catalyzed cross-coupling. It allows the direct use of tosylhydrazones of ketones and aldehydes as nucleophilic synthons for cross-coupling, without the preliminary formation of an organometallic reagent. This method gives an easy access to various polysubstituted styrenes and alkenylated heteroarenes.