Download PDF
Synfacts 2007(11): 1118-1118  
DOI: 10.1055/s-2007-991205
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Microcladallene

Contributor(s): Philip Kocienski, Stewart Eccles
J. Park, B. Kim, H. Kim, S. Kim, D. Kim*
Seoul National University, Korea
Further Information

Publication History

Publication Date:
23 October 2007 (online)

    Permissions and Reprints

Significance

(+)-Microcladallene was isolated from Laurencia microcladia, a red alga. A salient feature of the synthesis is the installation of a secondary bromoalkane function by nucleophilic substitution of a sulfonate ester (E to F) with retention of configuration using a nucleophile-assisting leaving group.