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Hepatoprotective activity from various parts of Sonneratia caseolaris
Sonneratia caseolaris L., family Sonneratiaceae, is well-known as mangrove tree which commonly found in mud lagoon. In Asia, its fruit and flower were used as vegetable and traditional medicines for cough and anti-parasites. The hepatoprotective activity of the methanolic extract from the different parts of S. caseolaris, stamen, sepal, meat of fruit, skin of fruit and persistent calyx, seed and pneumatophore, were investigated in HepG2 cells using MTT assay for cell viability determination. All crude extracts could protect the cell damage against chloroform toxicity. The hepatoprotective activities increased in the methanolic extracts obtained from various parts of S. caseolaris sepal, seed, skin of fruit and persistent calyx, pneumatophore, stamen, and meat of fruit, respectively, at a concentration of 50µg/ml. The sepal extract could inhibit the chloroform toxicity in a concentration dependent manner and its activity was higher than that of silymarin, which was employed as the positive control. From this presented results it is suggested that S. caseolaris is a potential plant to further investigate for developing as hepatoprotective agent.
Acknowledgements: Thailand Research Fund and Faculty of Pharmacy, Silpakorn University
References:  Perry, L.M. 1980. Medicinal plants of east and southeast asia. MIT Press, Cambridge.  Mossman, T. J. (1983) Immunol. methods. 65: 55.