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© Georg Thieme Verlag KG Stuttgart · New York
Flavan-3-ol-Phenylpropanoid Conjugates from Anemopaegma arvense and their Antioxidant Activities
Received: December 18, 2006
Revised: June 4, 2007
Accepted: June 8, 2007
20 July 2007 (online)
One of the species of commercially available catuaba was identified as Anemopaegma arvense by comparison of its micromorphological characteristics and TLC profile with six species of authenticated plants that are commonly referred to as catuaba. The bioactivity-guided fractionation of the ethyl acetate extract of the stem bark of this catuaba sample resulted in the isolation of one new (1, catuabin A) and three known flavan-3-ol type phenylpropanoids, cinchonain Ia (2), cinchonain IIa (3), and kandelin A1 (4) with antioxidant activities. The structures of these compounds were determined by a combination of spectroscopic techniques. Additionally, these compounds were tested for their anti-inflammatory, cytotoxicity, antimalarial, and antimicrobial activities, where no activity was observed.
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Ikhlas A. Khan, Ph.D
National Center for Natural Products Research
Research Institute of Pharmaceutical Sciences and Department of Pharmacognosy
School of Pharmacy
The University of Mississippi