Planta Med 2003; 69(10): 933-938
DOI: 10.1055/s-2003-45103
Original Paper
Natural Product Chemistry
© Georg Thieme Verlag Stuttgart · New York

Antimicrobial Compounds from Pimpinella Species Growing in Turkey

Nurhayat Tabanca1 , 2 , Erdal Bedir2 , Nese Kirimer1 , K. Husnu Can Baser1 , Shabana I. Khan2 , Melissa R. Jacob2 , Ikhlas A. Khan2 , 3
  • 1Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey
  • 2National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, The University of Mississippi, University, MS, USA
  • 3Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA
This research was supported by Anadolu University Research Fund, Eskisehir, Turkey (AUAF No: 00 03 34), and in part by the United States Department of Agriculture, Agricultural Research Service Specific Cooperative Agreement No. 58-6408-2-0009
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Publikationsverlauf

Received: March 28, 2003

Accepted: June 28, 2003

Publikationsdatum:
02. Dezember 2003 (online)

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Abstract

A new, 4-(2-propenyl)-phenyl angelate (1) and four known phenylpropanoids (2 - 5), were isolated from Pimpinella isaurica, a species endemic in Turkey. One new sesquiterpene, 1-methyl-4-(5-methyl-1-methylenehex-4-enyl)-7-oxabicyclo[4.1.0]heptane (6) was obtained from P. aurea and two known phenylpropanoids were isolated (7, 8), from P. corymbosa. The structure elucidation of the new compounds 1 and 6 was achieved by a combination of one- (1H, and 13C) and two-dimensional NMR techniques (G-DQF-COSY, G-HMQC, and G-HMBC) and LC-ESI-FTMS. Compounds 1, 2, 4, 6, 7, 8 have been evaluated for their antimalarial and antimicrobial activities. Compound 1, 2, 4, 6, 8 had antimicrobial activity against Mycobacterium intracellulare with IC50 values of 7.0, 15.0, 2.5, 10.0 and 1.5 μg/mL, respectively.

References

Ikhlas A. Khan, Ph.D.

National Center for Natural Products Research

Research Institute of Pharmaceutical Sciences

Department of Pharmacognosy

School of Pharmacy

The University of Mississippi

University

MS 38677

USA

Telefon: +1-662-915-7821

Fax: +1-662-915-7062

eMail: ikhan@olemiss.edu