A Controlled Study of the Efficacy and Safety of Mianserin and Amitriptyline in Depressive Inpatients

H.-J. Möller; S. Kasper; H. Müller; W. Kissling; J. Fuger; S. Ruhrmann

doi:10.1055/s-2007-979611

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Pharmacopsychiatry 1995; 28(6): 249-252
DOI: 10.1055/s-2007-979611

Original Paper

A Controlled Study of the Efficacy and Safety of Mianserin and Amitriptyline in Depressive Inpatients

H.-J. Möller¹ , S. Kasper² , H. Müller³ , W. Kissling⁴ , J. Fuger³ , S. Ruhrmann³

¹Department of Psychiatry, Ludwig Maximilians University, Munich, Germany
²Department of Psychiatry, University of Vienna, Austria
³Department of Psychiatry, University of Bonn, Germany
⁴Department of Psychiatry, Technical University of Munich, Germany

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Publication History

Publication Date:
23 April 2007 (online)

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Abstract

As with other second-generation antidepressants, the anti-depressive efficacy of mianserin was investigated in double-blind control group studies, mostly under outpatient conditions. This study tested the antidepressive efficacy and safety of mianserin as compared to amitriptyline in a sample of 51 depressed inpatients suffering from major depression. No statistically significant difference was found with regard to the main efficacy outcome criterion, the HAMD. The tolerability results demonstrated a superiority of mianserin with respect to vegetative symptoms and especially with respect to dryness of the mouth.