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Synfacts 2007(10): 1014-1014
DOI: 10.1055/s-2007-968953
DOI: 10.1055/s-2007-968953
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (±)-Salinosporamide A
G. Ma, H. Nguyen, D. Romo*
Texas A&M University, College Station, USA
Further Information
Publication History
Publication Date:
07 November 2007 (online)
Significance
Salinosporamide A is currently in clinical trials for the treatment of cancer. The molecule is also of interest due to the bicyclic core which the authors create by the bis-cyclization of keto acid D to give β-lactone J.