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Synfacts 2007(10): 1020-1020  
DOI: 10.1055/s-2007-968947
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Majusculone

Contributor(s): Philip Kocienski, Stewart Eccles
D. F. Taber*, M. I. Sikkander, P. H. Storck
University of Delaware, Newark, USA
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

Majusculone is a chamigrane sesqui­terpene that contains two spirocyclic six-membered rings. Central to this synthesis is the introduction of the quaternary spirocyclic center by an intramolecular insertion of an alkylidene carbene into a C-H bond.