Download PDF
Synfacts 2007(10): 1080-1080  
DOI: 10.1055/s-2007-968936
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Generally Applicable and Environment-Friendly Cyanation Protocol

Contributor(s): Paul Knochel, Tobias Thaler
T. Schareina, A. Zapf, W. Mägerlein, N. Müller, M. Beller*
Leibniz-Institut für Katalyse e.V. and der Universität Rostock and Saltigo GmbH, Leverkusen, Germany
Further Information

Publication History

Publication Date:
07 November 2007 (online)

    Permissions and Reprints

Significance

This novel cyanation protocol is the first method that efficiently allows the conversion of all kinds of aromatic and heteroaromatic bromides. Despite high reaction temperatures good to excellent selectivities and yields are obtained. Functional groups such as sensitive nitro groups are tolerated in this process. Aryl bromides with limited accessibility through bulky neighbouring groups are also efficiently cyanated.