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Synfacts 2007(8): 0784-0784  
DOI: 10.1055/s-2007-968716
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (6E)-2′-O-Methylmyxalamide D

Contributor(s): Philip Kocienski, Stewart Eccles
R. S. Coleman*, X. Lu, I. Modolo
The Ohio State University, Columbus, USA
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

(6E)-2′-O-Methylmyxalamide D was isolated from the myxobacterium Cystobacter fuscus and exhibits antibiotic and antifungal properties. This synthesis utilizes two palladium-catalyzed coupling reactions to elaborate the bis-metallated triene core E.