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Synfacts 2007(8): 0791-0791  
DOI: 10.1055/s-2007-968714
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Lyconadin A

Contributor(s): Philip Kocienski, Stewart Eccles
D. C. Beshore, A. B. Smith, III*
University of Pennsylvania, Philadelphia, USA
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Publication History

Publication Date:
24 July 2007 (online)

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Significance

(+)-Lyconadin A contains a synthetically challenging tetracyclic core. Access to this core was gained by formation of a tricyclic precursor in one step via an intramolecular aldol condensation followed by conjugate addition.