Synfacts 2007(7): 0683-0683  
DOI: 10.1055/s-2007-968690
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Pyrazoloquinolizinones via a Three-Component Reaction

Contributor(s): Victor Snieckus, Yigang Zhao
V. A. Chebanov*, V. E. Saraev, S. M. Desenko, V. N. Chernenko, S. V. Shishkina, O. V. Shishkin, K. M. Kobzar, C. O. Kappe
‘Institute for Single Crystals’ of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine; Karl-Franzens-Universität Graz, Austria; Technische Universität München, Garching, Germany
Further Information

Publication History

Publication Date:
22 June 2007 (online)


A microwave-assisted synthesis of pyrazoloquinolizinones by a 3-CR of aminopyr­azoles, aldehydes and 1,3-diketones is described. The reaction, carried out under strongly basic conditions directly affords the pyrazoloquinolizi­nones with the stereogenic centers in trans relationship. The scope of the reaction was insufficiently explored.