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Synfacts 2007(7): 0743-0743
DOI: 10.1055/s-2007-968645
DOI: 10.1055/s-2007-968645
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Arylation of Heterocycles via C-H Activation and Cross-Coupling with Aryl Chlorides
H. A. Chiong, O. Daugulis*
University of Houston, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2007 (online)
Significance
A new cheap and general method for the cross-coupling of heterocycles is presented in this article. A wide range of heterocycles was subjected to Pd-catalyzed C-H activation with subsequent cross-coupling to aryl and heteroaryl chlorides. This method was shown to be applicable to both electron-rich and electron-poor aryl chlorides furnishing good yields in almost all cases.