Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2007(7): 0681-0681
DOI: 10.1055/s-2007-968609
DOI: 10.1055/s-2007-968609
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Discodermolide
E. de Lemos, F.-H. Porée, A. Commerçon, J.-F. Betzer, A. Pancrazi, J. Ardisson*
Université de Cergy-Pointoise and Sanofi-Aventis, Vitry-sur-Seine, France
Further Information
Publication History
Publication Date:
22 June 2007 (online)
Significance
Discodermolide is a marine polyketide that displays pronounced anticancer activity. It is an antimitotic agent that acts by stabilizing microtubules. In this synthesis, the Hoppe crotyltitanation reaction (D. Hoppe, O. Zschage Angew. Chem. Int. Ed. 1989, 28, 69-71) plays a key strategic role to install the syn-anti methyl-hydroxy-methyl stereotriads prevalent throughout the structure.