Synthesis of Phalarine

Significance

Phalarine is a synthetically challenging furanobisindole alkaloid. Key to this synthesis is the cascade formation of F by rearrangement of azaspiroindolenine D. For a mechanistic discussion of this process, see: S. J. Danishefsky and co-workers Angew. Chem. Int. Ed. 2007, 46, 1444-1447.