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Synfacts 2007(5): 0520-0520  
DOI: 10.1055/s-2007-968440
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Fe(II)- and Zn(II)-Catalyzed Asymmetric Aqueous Mukaiyama Aldol Reactions

Contributor(s): Mark Lautens, Yann Béthuel
J. Jankowska, J. Paradowska, B. Rakiel, J. Mlynarski*
Polish Academy of Sciences, Warsaw, Poland
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

During recent years, Kobayashi, Wang, Li and co-workers have extensively studied the aqueous Mukaiyama aldol reactions with various metals. The most recent examples include praseodymium (J. Am. Chem. Soc. 2003, 125, 2989-2996) and gallium (Adv. Synth. Catal. 2005, 347, 1247-1256). In the present paper, the authors report a new hindered, lipophilic pybox ligand (t-BuPh2Si-protected) which is effective in iron(II) or zinc(II) catalysis.