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Synfacts 2007(5): 0461-0461  
DOI: 10.1055/s-2007-968396
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Methyl Monate C

Contributor(s): Philip Kocienski, Stewart Eccles
L. van Innis, J. M. Plancher, I. E. Markó*
Université Catholique de Louvain, Louvain-la-Neuve, Belgium and F. Hoffmann-La Roche Ltd., Basel, Switzerland
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Publication History

Publication Date:
24 April 2007 (online)

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Significance

Monic acid is the major component of the pseudomonic acids, antibiotics produced by Pseudomonas fluorescens. An intramolecular modified Sakurai cyclization was integral to the synthesis of methyl monate C along with a diastereoselective Tsuji-Trost allylation.