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Synfacts 2007(5): 0457-0457  
DOI: 10.1055/s-2007-968392
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Antibiotic GE2270A

Contributor(s): Philip Kocienski
K. C. Nicolaou*, B. Zou, D. H. Dethe, D. B. Li, D. Y.-K. Chen
Agency for Science, Technology, and Research, Singapore; The Scripps Research Institute and University of California, San Diego, La Jolla, USA
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Publikationsdatum:
24. April 2007 (online)

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Significance

G2270A is a thiopeptide antibiotic isolated from Planobispora rosea that inhibits bacterial elongation factor Tu but not the eukaryote elongation factor-1 alpha. The key step entails a hetero-Diels-Alder dimerization to generate the pyridine scaffold (red).