Synfacts 2007(4): 0370-0370  
DOI: 10.1055/s-2007-968379
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of 4-Quinazolinones under Green Conditions

Contributor(s): Victor Snieckus, Wei Gan
B. V. Lingaiah, G. Ezikiel, T. Yakaiah, G. V. Reddy, P. S. Rao*
Indian Institute of Chemical Technology and BASR Fine Chemicals, Hyderabad, India
Further Information

Publication History

Publication Date:
23 March 2007 (online)

Significance

A three-component, Nafion-H (perfluorinated resin-supported sulfonic acid) catalyzed synthesis of 4-(3H)-quinazolinones from isatoic anhydride or anthranilic acid, orthoesters and anilines is reported. As expected, anilines bearing EWG’s give higher yields of products than those with EDG’s. The substituent parameters R1 and R2 were insufficiently explored.