Synthesis of Vineomycinone B2 Methyl Ester

C.-L. Chen; S. M. Sparks; S. F. Martin

doi:10.1055/s-2007-968187

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2007(3): 0236-0236
DOI: 10.1055/s-2007-968187

Synthesis of Natural Products and Potential Drugs

Synthesis of Vineomycinone B₂ Methyl Ester

Contributor(s): Philip Kocienski
C.-L. Chen, S. M. Sparks, S. F. Martin*
University of Texas at Austin, USA

Further Information

Publication History

Publication Date:
20 February 2007 (online)

Permissions and Reprints

Significance

The vineomycins, metabolites of Streptomyces matensis vineus, are active against Gram-positive bacteria and murine sarcoma-180 tumors. The Martin synthesis is notable for its use of disposable silicon tethers to control the regiochemistry in two tandem benzyne-furan cycloadditions used to create the anthraquinone core.