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Severe bridging fibrosis of the colon in a man with inflammatory bowel disease
24. Oktober 2007 (online)
A 61-year-old man with diabetes and a history of alcohol abuse underwent colonoscopy for the investigation of anal incontinence and urgency of defecation. He had a history of inflammatory bowel disease (ulcerative colitis) and psoriasis from the age of 33 and was on long-term treatment with mesalazine. He had had several severe recurrences of his inflammatory bowel disease that had to be treated with corticosteroids (prednisolone), the last episode occurring at the age of 53.
Endoscopy of the colon did not reveal any lesions suggestive of a recurrence of the ulcerative colitis, but there was severe bridging fibrosis in the left colon and the sigmoid colon; there were also areas with pseudopolyps and a moderately severe stricture that was difficult to pass with the colonoscope ([Fig. 1]). Histological examination of the biopsies only showed some discrete inflammation within the lamina propria ([Fig. 2]). The patient was still in remission. Further neurological examination showed the incontinence to be multifactorial, due to neuritis associated with the history of diabetes and alcohol abuse.
Fig. 1 Colonoscopy showed severe bridging fibrosis in the left colon and the sigmoid colon (a,b). There were also areas with pseudopolyps and a moderately severe stricture that was difficult to pass with the colonoscope (c).
Fig. 2 Microscopic examination of the biopsies revealed no active inflammation. The inflammatory infiltrate consisted mainly of lymphocytes and plasmocytes.
Endoscopy with biopsy is an interesting method for the diagnosis and differential diagnosis of inflammatory bowel disease. It is also possible to determine disease activity and the effect and efficacy of medical treatment using this method . In this case we were confronted with a severe bridging fibrosis that had resulted from longstanding ulcerative colitis with several recurrences. Ulcerative colitis is an immunologically mediated disease characterized by chronic inflammation, which results in mucosal damage. Mesenchymal cells are thought to play an important role in the fibrotic process .
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- 2 Pucilowska J B, Williams K L, Lund P K. Fibrogenesis IV. Fibrosis and inflammatory bowel disease: cellular mediators and animal models. Am J Physiol Gastrointest Liver Physiol. 2000; 279 G653-G659
W. Van Moerkercke, , MD
Department of Internal Medicine
Gasthuisberg University Hospital
Fax: +32 16 34 43 07