Endoscopy 2007; 39: E114-E115
DOI: 10.1055/s-2007-966147
Unusual cases and technical notes

© Georg Thieme Verlag KG Stuttgart · New York

Thoracic myelolipoma diagnosed by endoscopic ultrasonography and fine-needle aspiration cytology

M.  Rossi1 , D.  Ravizza1 , G.  Fiori1 , C.  Trovato1 , G.  Renne2 , M.  J.  Miller2 , D.  Tamayo1 , C.  Crosta1
  • 1Endoscopy Division, European Institute of Oncology, Milan, Italy
  • 2Pathology Division, European Institute of Oncology, Milan, Italy
Further Information

Publication History

Publication Date:
18 April 2007 (online)

Myelolipomas are rare, benign, unilateral tumors of the adrenal gland, and are usually asymptomatic [1] [2]. Extra-adrenal myelolipomas are most commonly found in the presacral or other retroperitoneal regions; only 3 % of these tumors are found in the thorax [3].

A 73-year-old woman was referred to our division after a computed tomographic scan had revealed a bi-lobed mass, 7 cm in diameter, in the posterior mediastinum ([Figure 1]). Routine laboratory tests and positron emission tomography showed no abnormalities. Endoscopic ultrasonography was performed (FG38UX; Pentax, Tokyo, Japan) and the lesion appeared as an echo-rich, homogeneous mass with regular and well-demarcated borders ([Figure 2]). The mass did not appear to be associated with any nearby structures. Two passages with a fine needle (EUSN-3, 22 gauge; Cook, Limerick, Ireland) were performed without any complications. Fine-needle aspiration cytology (FNAC) showed the aspirate to be highly cellular, with erythroid and myeloid precursor cells intermixed with megakaryocytes, and immunoreactive for factor VIII. The cytologic diagnosis was consistent with extramedullary hematopoiesis ([Figure 3]). At surgery the lesion appeared soft, oval, smooth, and reddish, with yellow spots ([Figure 4]). The biopsy specimen showed mature adipose tissue intermixed with bone marrow elements ([Figure 5]), an appearance consistent with a histologic diagnosis of extra-adrenal myelolipoma.

Figure 1 A computed tomographic scan showing a 7-cm, bi-lobed paravertebral mass in the posterior mediastinum (arrows).

Figure 2 Ultrasonagraphic view of an echo-rich, homogeneous paraesophageal mass with regular and well-demarcated borders (arrows).

Figure 3 The cytologic smear showed numerous monocyte precursors, granulocytes, and erythrocytes in various phases of maturity, accompanied by giant multinucleated megakaryocytes (evident under high-power magnification). a A low-power view (hematoxylin and eosin [H&E] stain, original magnification × 200). b A high-power view (H&E stain, original magnification × 400). c View after immunostaining, showing immunoreactivity of the megakaryocytes for factor VIII (original magnificaton × 400).

Figure 4 Surgical exploration revealed a soft, oval, smooth lesion which appeared reddish with yellow spots (arrows).

Figure 5 Histologic section showing adipocytes surrounded by hematopoietic elements in various stages of maturity, including monocytes, granulocytes, and erythrocytes, and associated megakaryocytes (H&E stain, original magnifcation × 200).

The differential diagnosis of extra-adrenal myelolipoma and extramedullary hematopoiesis cannot be made purely on a cytologic basis, because these conditions both feature hematopoietic elements and adipose tissue [4]. However, extramedullary hematopoiesis occurs at multiple sites as a lobulated lesion in the thoracic paravertebral area that nestles against the costovertebral angle; extra-adrenal myelolipoma is usually a solitary lesion with a round or oval shape. Finally, extramedullary hematopoiesis is associated with anemia, usually in the patients with hemoglobinopathies, whereas anemia and other hematological disorders are not observed in extra-adrenal myelolipoma.

In conclusion, EUS-guided FNAC allowed us to exclude the presence of malignant cells in this patient, enabling us to plan an adequate surgical approach. EUS-guided FNAC proved to be effective and safe, even in the setting of extra-adrenal myelolipoma.



M. Rossi, MD

Division of Endoscopy

European Institute of Oncology

Via Ripamonti 435

20141 Milan


Fax: +39-02-57489353

Email: marzia.rossi@ieo.it