ABSTRACT
Two patients presenting with a stage I melanoma of the sole of the foot (Clark's level
IV, Breslow's 2.8 mm, and Clark's level IV, Breslow's 3.2 mm) underwent a 3-cm tumor
free-margin skin resection, followed by microanastomosed muscle flap reconstruction
(serratus anterior and latissimus dorsi). Immediately after primary wound healing,
an elective inguino-iliac lymph-node dissection, followed by hyperthermic isolated
regional chemotherapy with Melphalan, was carried out. Only moderate swelling of both
free flaps was observed after these procedures, and this resolved rapidly. The patients
returned to ambulation after 2 weeks. No other side effects of the hyperthermic isolated
regional chemotherapy were observed in the previously microanastomosed flaps.
