Planta Med 1999; 65(2): 162-164
DOI: 10.1055/s-2006-960455

© Georg Thieme Verlag Stuttgart · New York

Acute and Chronic Effects of Ginseng Total Saponin and Amphetamine on Fixed-Interval Performance of Rats

Alycia E. Halladay1 , Yi-Lung Lu2 , Jeanne Palmer1 , Ki-Wan Oh3 , George C. Wagner1
  • 1Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA
  • 2Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan ROC
  • 3College of Pharmacy, Chungbuk National University, Chungbuk, Cheongjiu, Korea
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04. Januar 2007 (online)


The effect of ginseng total saponin (GTS) on amphetamine (AMPH)-induced disruption of fixed-interval (Fl) responding in rats was examined. GTS (50 mg/kg) significantly improved the temporal responding impaired by 2 mg/kg of AMPH. A higher dose of 100 mg/kg GTS disrupted performance when given alone; this disruption was reversed by a low dose of AMPH (0.5 mg/kg) and tolerance developed to the effects of GTS with its repeated administration. Neurochemical analysis revealed that GTS (50 mg/kg) attenuated the increase in striatal dopamine caused by AMPH leading to the conclusion that brain dopamine may partially mediate the behavioral effects of GTS.