Acute and Chronic Effects of Ginseng Total Saponin and Amphetamine on Fixed-Interval Performance of Rats

Alycia E. Halladay; Yi-Lung Lu; Jeanne Palmer; Ki-Wan Oh; George C. Wagner

doi:10.1055/s-2006-960455

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Planta Med 1999; 65(2): 162-164
DOI: 10.1055/s-2006-960455

Letters

Acute and Chronic Effects of Ginseng Total Saponin and Amphetamine on Fixed-Interval Performance of Rats

Alycia E. Halladay¹ , Yi-Lung Lu² , Jeanne Palmer¹ , Ki-Wan Oh³ , George C. Wagner¹

¹Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA
²Institute of Behavioral Medicine, National Cheng Kung University, Tainan, Taiwan ROC
³College of Pharmacy, Chungbuk National University, Chungbuk, Cheongjiu, Korea

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Publication History

1998

1998

Publication Date:
04 January 2007 (online)

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Abstract

The effect of ginseng total saponin (GTS) on amphetamine (AMPH)-induced disruption of fixed-interval (Fl) responding in rats was examined. GTS (50 mg/kg) significantly improved the temporal responding impaired by 2 mg/kg of AMPH. A higher dose of 100 mg/kg GTS disrupted performance when given alone; this disruption was reversed by a low dose of AMPH (0.5 mg/kg) and tolerance developed to the effects of GTS with its repeated administration. Neurochemical analysis revealed that GTS (50 mg/kg) attenuated the increase in striatal dopamine caused by AMPH leading to the conclusion that brain dopamine may partially mediate the behavioral effects of GTS.

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