Structure and in vitro Antiviral Activity of Triterpenoid Saponins from Calendula arvensis*

Nunziatina De Tommasi; Cinzia Conti; Maria Luisa Stein; Cosimo Pizza

doi:10.1055/s-2006-960084

Planta Medica, Table of Contents

Planta Med 1991; 57(3): 250-253
DOI: 10.1055/s-2006-960084

Papers

Structure and in vitro Antiviral Activity of Triterpenoid Saponins from *Calendula arvensis**

Nunziatina De Tommasi¹ , Cinzia Conti² , Maria Luisa Stein³ , Cosimo Pizza¹

¹Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli, Via D. Montesano 49, I-80131 Napoli, Italy
²Istituto di Microbiologia, Facoltà di Medicina, Università degli Studi “La Sapienza”, P. le Aldo Moro 5, I-00185 Roma, Italy
³Dipartimento di Studi farmaceutici, Università degli Studi “La Sapienza”, P. le Aldo Moro 5, I-00185 Roma, Italy

* This work is dedicated to Professor Giovanni Battista Marini-Bettolo on the occasion of his 75th birthday.

Abstract

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Abstract

A reinvestigation of the aerial parts of Calendula arvensis afforded, in addition to the oleanolic acid glycosides 1-4(4), the new glycoside 5 whose structure was elucidated by spectral and chemical studies and determined as 3-O-{β-D-galactopyranosyl-(1→3)[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranosyl}oleanolic acid (28→1)-β-D-glucopyranosyl ester. Furthermore, some antiviral tests were performed on glycosides 1-5 and on 5a, the hydrolysis product of 5, towards vesicular Stomatitis virus (VSV) and rhinovirus (HRV) infection in cell cultures. An inhibitory effect against VSV multiplication was observed for all the Compounds tested while HRV replication was significantly affected only by compound 3.

Key words

Calendula arvensis - oleanolic acid glycosides - vesicular stomatitis virus - rhinovirus - antiviral activity

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