© Georg Thieme Verlag Stuttgart · New York
An Analytical Study and Anti-Inflammatory and Analgesic Effects of Harpagophytum procumbens and Harpagophytum zeyheri
04 January 2007 (online)
The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8-p-coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8-p-coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix.
Harpagophytum procumbens - Harpagophytum zeyheri - Pedaliaceae - harpagoside - 8-p-coumaroylharpagide - anti-inflammatory activity - analgesic activity