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Synfacts 2007(2): 0199-0199  
DOI: 10.1055/s-2006-955796
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Oxidative Cross-Coupling of Alkylzinc and Alkynylstannanes

Contributor(s): Paul Knochel, Andrei Gavryushin
Y. Zhao, H. Wang, X. Hou, Y. Hu, A. Lei*, H. Zhang, L. Zhu
Wuhan University, P. R. of China
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

The procedure described by the authors is an oxidative C-C bond formation. It uses inexpensive and readily available desyl chloride as a reoxidant for Pd(0) in the cross-coupling between two organometallic species: an alkylzinc and an alkynylstannane. The method is operationally simple and affords a broad range of substituted alkynes with a good functional group tolerance. It opens also good perspectives for the development of new types of C-C bond forming reactions.