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Synfacts 2006(11): 1097-1097  
DOI: 10.1055/s-2006-949392
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-(19R)-Ibogamin-19-ol

Contributor(s): Philip Kocienski, Thomas Snaddon
S. Höck, H.-J. Borschberg*
Eidgenössische Technische Hochschule, Zürich, Switzerland
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Publikationsverlauf

Publikationsdatum:
24. Oktober 2006 (online)

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Significance

This synthesis of the indole alkaloid (-)-(19R)-ibogamin-19-ol features the use of an Ireland-Claisen rearrangement and an intramole­cular [3+2] cycloaddition to assemble the azabicy­clo[2.2.2]octane core F.